Central Nervous Sytem

January 26, 2024

This suggested that the central nervous system not only controlaa angiotensinaa adrenergic discharge, but also the release and synthesis of many substances at peripheral tissue and circulating cells (monocytes and lymphocytes) when they make a station-level bodies nodes. PATHOPHYSIOLOGY a Angiotensin II increases peripheral vascular resistance as triggers in the central nervous system, areas (circumventriculares organs, organ vasculosa of the lamina terminalis, supraoptic nucleus, hypothalamus, nucleus of the solitary tract, nucleus ambiguus, amygdala) that regulate blood pressure, heart rate, blood volume and extracellular sodium. to angiotensin II acting at AT-1 receptor causes most of the pathophysiological changes at the cardiovascular system described in hypertension, these are: 1 .- increased peripheral resistance (vasoconstriction). 2 .-. Hypertrophy, cardiac enlargement with interstitial hyperplasia miocitoa ea. 3 .- Excess sodium reabsorption at the renal tubular.

4 .- increased nephrin, a pro-inflammatory proteinaa expressed in glomerular podocytes. 5 .- increased recruitment of leukocytes (leukocyte migration activation) 6 .- serotonin release with the consequent formation of edema. 7 .- release of interferon gamma. 8 .- mononuclear phagocytic system activation with release of TNF-alpha and proinflammatory cytokines inflammatory and IL-6 and IL-1, through the NFK-B translocation to the nucleus .- 9 activation of cyclooxygenases. 10 .- Activation of oxidative stress with increased free radicals mediated by cytokines, amines, endothelin and prostaglandins. 11 .- half the production of PDGF (platelet-derived factor), accelerating the processes of fibrosclerosis. 12 .- increased extracellular matrix (interstitial fibrosis with fibroblastic proliferation) and apoptosis. 13 .- Increases the secretion of aldosterone 14 .- interacts with the insulin receptor substrate (IRS-1) 15 .- Inhibition of PPAR gamma (they are a subfamily of intracellular receptors) that regulate the homeostasis of glucose and lipids closely linked AT-1 receptor of angiotensin II, however, in the body there is a regulatory system that opposes these effects such as angiotensin II receptor subtype AT-2 and atrial natriuretic peptide system.

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